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ORIGINAL RESEARCH REPORT
Year : 2001  |  Volume : 1  |  Issue : 1  |  Page : 19-21

Packed Cell Volume and Creatinine Clearance in Children With Cyanotic Congenital Heart Disease


Department of Paediatrics, College of of Medicine, University of Lagos, PMB 12003, Lagos

Correspondence Address:
J K Renner
Department of Paediatrics, College of of Medicine, University of Lagos, PMB 12003, Lagos

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Source of Support: None, Conflict of Interest: None


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Objective: To determine the relationship between glomerular filtration rate (GFR) and packed cell volume (PCV) in patients with cyanotic congenital heart disease (CCHD) in steady state. Subjects and Methods: Nineteen children with CCHD and 27 control children were studied. The GFR was determined using endogenous creatinine clearance (Ccr). Results: The mean+SD GFR in cyanotic congenital heart disease patients was 74.7+35.6mls/min/ 1.73m2 while that of controls was77.0+27.2mls/min/1.73m2 (p>0.05). The mean PCV of cyanotic subjects (62.3%) was significantly higher than that of controls (35.2%) (p<0.001). The correlation between PCV and GFR in the cyanotic subjects was r = 0.46, while the figure for control was 0.14. Conclusion: In spite of the significantly higher PCV of cyanotic subjects, GFR is still preserved within normal limits.


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