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ORIGINAL RESEARCH REPORT
Year : 2001  |  Volume : 1  |  Issue : 1  |  Page : 22-24

Blood Pressure Lowering Effect of the Seeds of Vitex doniana


1 Department of Pharmaceutical Chemistry, School of Pharmacy, College of Medicine, University of Lagos, Idi-Araba, PMB 12003, Lagos
2 Department of Clinical Pharmacy, School of Pharmacy, College of Medicine, University of Lagos, Idi-Araba, PMB 12003, Lagos
3 Institute of Child and Primary Health Care, College of Medicine, University of Lagos, Idi-Araba, PMB 12003, Lagos

Correspondence Address:
K A Ogbeche
Department of Pharmaceutical Chemistry, School of Pharmacy, College of Medicine, University of Lagos, Idi-Araba, PMB 12003, Lagos

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Source of Support: None, Conflict of Interest: None


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Objective: To determine the anti-hypertensive properties of the seeds of Vitex doniana, family Verbenaceae, a medicinal plant used in the middle belt of Nigeria for its therapeutic values. Methodology: Oral and intravenous preparations of vitex doniana were administered to normotensive, hypertensive and spontaneous hypertensive female moster rats. Results: Oral and intravenous administration of the seed extract produced a dose-dependent hypotensive effect in both normotensive and hypertensive rats. The blood pressure was markedly reduced and the level maintained for longer duration when the extract was administered intravenously to hypertensive rats. A significant reduction in the mean arterial pressure (MAP) in both normotensive rats (p<0.01) and spontaneous hypertensive rats (p<0.001) was obtained, using orally dosed seed extract of 300mg/kg body weight. Conclusion: The results have shown that Vitex doniana seeds have a blood pressure lowering effect and may therefore prove useful as an antihypertensive agent.


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