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Year : 2003  |  Volume : 3  |  Issue : 2  |  Page : 1-4

The Circadian Rhythm of Blood Glucose in Adult Male Sprague-Dawley Rats in Lagos

Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria

Correspondence Address:
O A Okanlawon
Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba, Lagos
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Source of Support: None, Conflict of Interest: None

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Aim/Objective: The aim of this study was to identify and characterize the rhythm of blood glucose levels within a 24-hour period in rats kept under standard photoperiodic conditions of 12 hours of light alternating with 12 hours of darkness in the Department of Anatomy, College of Medicine, University of Lagos. Subjects/Materials/Method: 30 adult male Sprague-Dawley rats weighing 150-170g were used. Basal blood glucose levels were taken at 0700h (week 1) in all the rats after an unrestricted overnight access to food and water. Following an interval of one week (i.e. week 3), the fasting blood glucose levels of all the animals were also determined at 0700h (i.e. after 12 hours of overnight fasting). 4-hourly serial blood glucose levels were then determined at 0700, 1100, 1500, 1900, 2300 and 0300h (week 5) in all the rats and these were repeated after two weeks (week 8). Prior to each sampling of the serial blood glucose assessments, the animals were allowed unrestricted access to food and water in the first one-hour while they were fasted for the following 3 hours. Result: The results of our study showed that the blood glucose level varied with the time of the day. The mean basal blood glucose at 0700h after an unrestricted access to food and water was 85.33 ± 6.02 mg/dL while the mean fasting blood glucose at 0700h was 41.33 ± 1.69 mg/dL. The mean serial blood glucose levels at 0700, 1100, 1500, 1900, 2300 and 0300h in week 5 were 63.31 ± 5.72, 54.78 ± 3.55, 69.98 ± 4.78, 80.78 ± 5.08, 69.02 ± 5.61and 76.58 ± 6.13 mg/dL while the values obtained in week 8 were 62.95 ± 5.02, 53.88 ± 2.98, 71.36 ± 5.69, 83.88 ± 6.04, 65.64 ± 4.12 and 73.08 ± 5.01 mg/dL respectively. There were statistically significant differences (p< 0.05) between the nadir and peak values obtained. Levels remained relatively higher during the scotophase than in the photophase. Conclusion: We conclude that blood glucose level in Sprague-Dawley rats subjected to scheduled feeding in Lagos exhibits circadian rhythm with peak at 1900h and nadir at 1100h.

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