ORIGINAL RESEARCH REPORT
Year : 2023 | Volume
: 20 | Issue : 1 | Page : 15--21
Clinical characteristics and outcome of patients admitted during the first and second waves of COVID-19 pandemic at a Tertiary Hospital in Lagos, Nigeria
Iorhen Ephraim Akase1, Patricia Eyanya Akintan2, Erereoghor Otrofanowei1, Oluwarotimi Bolaji Olopade3, Gbenga Olorunfemi4, Adefolarin Opawoye3, Felix M Alakaloko5, Uyiekpen Emmanuel Ima-Edomwonyi3, Yeside Olubunmi Akinbolagbe2, Osigwe Paul Agabi1, Danladi Abraham Nmadu3, Gbemileke O Akinbode5, Aramide C Olasope3, Adewale Ogundare3, Abiola Bukunmi Bolarinwa6, Oluwakemi Elizabeth Awojumobi-Otokiti6, Precious J Enajeroh3, Moses Karami3, Christopher Imokhuede Esezobor3, Yewande O Oshodi7, Oluwole Ayodeji Ayotunde8, Wasiu Lanre Adeyemo9, Christopher O Bode10
1 Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria
2 Department of Pediatrics, College of Medicine, University of Lagos, Lagos, Nigeria
3 Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria
4 Division of Epidemiology and Biostatistics, University of Witwatersrand, Johannesburg, South Africa
5 Department of Surgery, Lagos University Teaching Hospital, Lagos, Nigeria
6 Department of Hematology and Blood Transfusion, Lagos University Teaching Hospital, Lagos, Nigeria
7 Department of Psychiatry, College of Medicine, University of Lagos, Lagos, Nigeria
8 Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria
9 Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Lagos, Nigeria
10 Department of Surgery, College of Medicine, University of Lagos, Lagos, Nigeria
Correspondence Address:
Dr. Iorhen Ephraim Akase
Department of Medicine, Infectious Diseases Unit, College of Medicine, University of Lagos, Lagos
Nigeria
Introduction: Clinical data on the differences in presentation and outcome of admitted COVID-19 patients in Nigeria are limited. This study aimed to compare the first and second waves of the COVID-19 pandemic in a Tertiary Hospital in Lagos and describe the clinical differences between the waves, the severity of COVID-19, and the mortality differences. Methods: The study was a retrospective review of the medical records of all children and adults admitted to the Lagos University Teaching Hospital (LUTH) COVID-19 Isolation and Treatment Centre during the first wave (from April 2020 to October 2020) and second wave (from December 2020 to April 2021). The clinical characteristics (including COVID severity) and outcome among admitted patients during the two waves were compared. Results: Between April 2020 and April 2021, 602 patients were admitted to LUTH for COVID-19. Patients in the first wave were significantly younger (43 vs. 54.5 years), more in number (53.8% vs. 46.2%), and had a higher proportion of health-care workers than those in the second wave (14.5% vs. 6.5%). Comorbidities were present in more than half of the patients hospitalized for COVID-19 infection (51.0%). This proportion was much higher during the pandemic's second wave (41.7% vs. 61.9%, P < 0.001). The most common comorbidity found in hospitalized patients was hypertension (37.0%). Patients admitted during the second wave had shorter stays (11 vs. 7 days) and similar mortality rates (10.2% vs. 10.8%). Conclusion: The first and second waves had comparable mortality rates though patients in the first wave were younger and there were more healthcare providers in the cohort. Patients admitted to the second wave however had more comorbidities but shorter lengths of stay which may suggest a better understanding of the infection and better outcome.
How to cite this article:
Akase IE, Akintan PE, Otrofanowei E, Olopade OB, Olorunfemi G, Opawoye A, Alakaloko FM, Ima-Edomwonyi UE, Akinbolagbe YO, Agabi OP, Nmadu DA, Akinbode GO, Olasope AC, Ogundare A, Bolarinwa AB, Awojumobi-Otokiti OE, Enajeroh PJ, Karami M, Esezobor CI, Oshodi YO, Ayotunde OA, Adeyemo WL, Bode CO. Clinical characteristics and outcome of patients admitted during the first and second waves of COVID-19 pandemic at a Tertiary Hospital in Lagos, Nigeria.J Clin Sci 2023;20:15-21
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How to cite this URL:
Akase IE, Akintan PE, Otrofanowei E, Olopade OB, Olorunfemi G, Opawoye A, Alakaloko FM, Ima-Edomwonyi UE, Akinbolagbe YO, Agabi OP, Nmadu DA, Akinbode GO, Olasope AC, Ogundare A, Bolarinwa AB, Awojumobi-Otokiti OE, Enajeroh PJ, Karami M, Esezobor CI, Oshodi YO, Ayotunde OA, Adeyemo WL, Bode CO. Clinical characteristics and outcome of patients admitted during the first and second waves of COVID-19 pandemic at a Tertiary Hospital in Lagos, Nigeria. J Clin Sci [serial online] 2023 [cited 2023 May 28 ];20:15-21
Available from: https://www.jcsjournal.org/article.asp?issn=2468-6859;year=2023;volume=20;issue=1;spage=15;epage=21;aulast=Akase;type=0 |
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